ICD-10-CM Coding Rules. Pelvic pain and cramping may start before a menstrual period and last for days into it. The conversion of. TVUS permits rapid assessment of size, position, and presence of uterine fibroids. Introduction. Abstract. Vaginal bleeding or discharge. It causes your uterus to thicken and enlarge — sometimes, up to double or triple its usual size. Bookshelf ID: NBK542229 PMID: 31194386. Constipation or pain with bowel movements. Women with a proliferative endometrium had a higher risk of developing endometrial hyperplasia or cancer (11. Lower back pain. Bleeding in between menstruation. 10x H/E. AEH is a precancerous condition where the lining of the uterus is too thick, and the cells become abnormal. Lipid. Hormone Therapy: Treatment in which estrogen and often progestin are taken to help relieve symptoms that may happen around the time of menopause. Throughout the reproductive years, the cyclical hormonal changes of the menstrual cycle provide a continuously changing morphologic spectrum. 1. 5%. Cytologically, these glands did not have the features of atrophy, disordered proliferative endometrium or cystic hyperplasia, and showed only weak. Uterine polyps, also called endometrial polyps, are small, soft growths on the inside of a woman’s uterus, or womb. Sex might hurt. In contrast, their biological activity is varied, depending on the chemical structure, pharmacokinetics, receptor affinity and different potency of action. The clinical significance of EH lies in the associated risk of progression to endometrioid endometrial cancer (EC) and ‘atypical’ forms of EH are regarded as premalignant lesions. Still, it’s one of the most essential. It is predominantly characterized by an increase in the endometrial gland-to-stroma ratio when compared to normal proliferative endometrium. Furthermore, 11. The symptoms of endometriosis can vary. Pain in the pelvis, feeling a mass (tumor), and losing weight without trying can also be symptoms of endometrial cancer. Endometrial biopsy. EIN, or even adenocarcinoma. HRT continues to be commonly used as short-term therapy for symptoms related to. The most common sign of endometriosis is pain in your lower belly that doesn’t go away. which are expressed in the endometrium throughout the proliferative phase and reach a peak in the mid-secretory phase under the influence of. Disordered proliferative endometrium has scattered cystically dilated glands but a low gland density overall. Secretory endometrium looks much different than proliferative endometrium. 002), atypical endometrial hyperplasia (2. 1. Endometrial metaplasias and changes (EMCs) are conditions frequently overlooked and misdiagnosed. Symptoms. Epithelium (endometrial glands) 2. The presenting symptoms for premalignant lesions are menorrhagia and metrorrhagia (type 1) and postmenopausal bleeding (type 2). Bone broth (alternatively, gelatin broth) Anti-inflammatory foods (leafy vegetables, broccoli, celery, blueberries, salmon or fish oil) Caster oil is a common home remedy for endometritis. During the same period, there are concurrent changes in the endometrium, which is why the follicular phase is also known as the proliferative phase. Dr. Present is proliferative endometrium with scattered cysts and stromal breakdown forming stromal balls and collapsed eosinophilic epithelium. Created for people with ongoing healthcare needs but benefits everyone. A comparison of proliferative endometrial transcriptomes from women with and without adenomyosis identified 140 upregulated and 884 downregulated genes in samples from those affected, as well as microRNAs of unclear importance. Progesterone is. Endometrial hyperplasia (EH) is a proliferation of endometrial glands which is typically categorized into two groups: EH without atypia (usually not neoplastic) and EH with atypia (neoplastic; also referred to as endometrial intraepithelial neoplasia [EIN]). 5 (range—53–71) years, for the atrophic endometrium patients, it was 67. Postmenopausal bleeding (PMB) affects about 10% of all women and endometrial hyperplasia (EH) is the etiology in about 15% of cases 1-4. Endometriosis is defined by the presence of endometrial glands and stroma in extrauterine locations. Endometrial polyps refer to overgrowths of endometrial glands and stroma within the uterine cavity. Pelvis massage to reduce pressure and relieve pain. . This tissue consists of: 1. Progestins (progesterone and derivatives) transform proliferative endometrium into secretory endometrium. If pregnancy doesn’t happen, your estrogen and progesterone levels drop. Metaplasia is defined as a change of one cell type to another cell type. Symptoms. Immune dysfunction includes insufficient immune lesion clearance, a pro-inflammatory endometrial environment, and systemic inflammation. An unusually thick endometrium causes various symptoms, such as longer and heavier periods. Stromal staining of Ki67 was found to be more apparent in the secretory phase, however, it was found to be lower than that of the endometrial glands in the proliferative phase. This hormone gets your uterus ready to receive an egg. Proliferative endometrium is a very common non-cancerous change that develops in the tissue lining the inside of the uterus. endometrium cells spreading through the body in the bloodstream or lymphatic system, a series of tubes and glands that form part of the immune system;Only in postmenopaus: The endometrium is the lining of the uterus, and it 'proliferates' during the 1st 1/2 of the menstrual cycle under the influence of the estrogen that. Your GP probably hadn't had time or knowledge that the report was ready to read. It undergoes cyclical change regulated by the fine balance between oestrogen and progesterone. Some fragments may represent. Pain during sex is. 5 mg E2/50 mg P4) to 2. Only in postmenopaus: The endometrium is the lining of the uterus, and it 'proliferates' during the 1st 1/2 of the menstrual cycle under the influence of the estrogen that. 40. Furthermore, 11. The proliferation phase follows. The metaplasia doesn't mean anything significant, and the glandular and stromal breakdown. Signs and symptoms include pelvic discomfort and ovarian cysts, as well as digestive complaints, such as nausea, diarrhea or constipation. and clinical symptoms in patients with uterine leiomyomas scheduled for hysterectomy. During the proliferative phase, the endometrium responds to the endocrine environment to undergo extensive proliferation. In the present work, we. Marilda Chung answered. In peri-menopausal age group proliferative endometrium (35. Summary. The proliferative phase begins when your period stops. The endometrial thickness (ET) varies according to the phases of the menstrual cycle. Within the endometrium of fertile women, miR-29c is differentially regulated across the fertile menstrual cycle: it is elevated in the mid-secretory, receptive phase compared to the proliferative phase (Kuokkanen et al. In the human endometrium, estrogen drives tissue repair and epithelial proliferation during the proliferative phase and estrogen and progesterone promote thickening of the endometrium following ovulation. Compared with the normal proliferative endometrium, the predominant characterization of EH is an increased endometrial gland-to-stroma ratio. The endometrium repairs itself and it becomes. The glands are involved in. Atrophic endometrium is a normal finding in prepubertal, postmenopausal, and some perimenopausal women. However, treating menopause. No racial or ethnic group predilection is observed, although Caucasians are at a higher risk for some. The findings in endometrial biopsies taken for abnormal uterine bleeding can show a wide range of appearances that reflect the cyclical changes in the endometrium in women during their reproductive years; accordingly, the histopathological diagnosis provides a description of the features observed microscopically (e. 8%; P=. Disordered proliferative endometrium accounted for 5. It is an inflammatory, estrogen-dependent condition associated with pelvic pain and infertility. The endometrium is affected by a single estrogen showing obvious proliferative changes, and the endometrium cannot be well transformed into the secretory phase [4–6]. 4%; P=. Often, however, an organic cause is not identifiable and curettage may show atrophic endometrium (3) proliferative endometrium (4) and rarely secretory endometrium (5). Its inner lining, the endometrium, holds exceptional remodeling capacity, undergoing monthly cycles of growth (proliferative phase), differentiation (secretory phase), degeneration (menstrual phase) and regeneration with the restart of the cycle (). Contributed by Fabiola Farci, MD. 1%) cases presented with an endometrial thickness of 6–10 mm. Converts endometrium from proliferative to secretory C. The pathologist must be aware of the spectrum of endometrial metaplasias encountered and the clinical setting in which they. Symptoms of a disordered proliferative endometrium depend on. It is usually treated with a total hysterectomy but, in some cases, may also be. The cystic endometrial hyperplasia-pyometra (CEH-Pyo) complex is the most frequent and important uterine disorder in queens [ 1 – 5 ]. The line denotes approximately 1 mm (hematoxylin-eosin, original magnification ×4). Symptoms of both include pelvic pain and heavy. 2, 34 Endometrioid. Duration of therapy did not correlate with symptoms of BTB or endometrial histology. C. Sometimes, adenomyosis causes no signs or symptoms or only mild discomfort. The 2024 edition of ICD-10-CM N85. The leading symptoms of EH are bleeding disorders in premenopausal women and vaginal bleeding in postmenopausal women. The non-neoplastic endometrium adjacent to an endometrial adenocarcinoma was active in 43 of the 50 women; four were in the form of weakly proliferating glands and 39 in the form of a mixed inactive and weakly proliferative endometrium. If cramping wasn’t enough,women with endometriosis sometimes. They come from the tissue that lines the uterus, called the endometrium. The find-ings of this study suggest that long-term monitoring is warranted for women with postmenopausal bleeding and a proliferative endometriumProliferative endometrium with no atypia or malignancy Proliferative endometrium with no atypia or malignancy Nil 8 weeks 4 Normal & 10mm Normal apart from a small polyp Proliferative endometrium with no atypia or malignancy Proliferative endometrium with no atypia or malignancy MDPA 100mg BD for 6 to 8 weeks 8 weeks 3. This layer. Treatment is. Endometrial hyperplasia is a condition that causes abnormal uterine bleeding. Pain during sexual intercourse. It is diagnosed by a pathologist on examination of endometrial tissue under a microscope. Infertility (being unable to become pregnant or carry a pregnancy to term). 11,672. Pelvic pain. Demographics. Pain during or after sex is common with endometriosis. Endometrial dating. Use of contraceptive steroids or other hormones can cause alterations, such as decidual change or endometrial gland atrophy. It is diagnosed by a pathologist on examination of endometrial tissue under a microscope. If left untreated, disordered proliferative endometrium can change into another non-cancerous condition called. Our results showed that 90. Bleeding or spotting between periods (intermenstrual bleeding). Symptoms?: I assume this was a result of an endometrial biopsy done for heavy or irregular bleeding. Michael Swor answered. Dr. have fewer risks and side effects and are equally effective for managing menopausal symptoms. These changes at the level of. Benign endometrial hyperplasia. Evaluation for. Endometriosis affects nearly 10% of women of reproductive age, and 30% to 50% of those with the condition suffer from chronic pelvic pain and/or infertility, the two major clinical symptoms (1,. The most common clinical symptoms include pelvic pain and infertility which can seriously influence the quality of. Endometriosis is a reproductive disorder in which endometrial tissue is aberrantly located outside the uterus. If pregnancy doesn’t happen, your estrogen and progesterone levels drop. Endometrial metaplasias and changes (EMCs) are conditions frequently overlooked and misdiagnosed. Among those women, 278 had a proliferative endometrium, and 684 had an atrophic endometrium. Pelvic pain, a mass, and weight loss. Progesterone is normally the first hormone to decrease as we approach menopause. What are symptoms of endometrial atrophy? Symptoms. Symptoms. If conception takes place, the embryo implants into the endometrium. This is the American ICD-10-CM version of N85. 5%). An occasional mildly dilated gland is a normal feature and of. Still, any delay in seeking medical help may allow the disease to progress even further. It is diagnosed by a pathologist on examination of. Your doctor could order an endometrial biopsy for several reasons: Abnormal bleeding from the vagina: In post-menopausal women, this would mean any bleeding at all. Read More. Applicable To. Endometrial cancer is the most common gynecologic malignancy. It also displays anti-proliferative effects in non. Pain occurs in the. Uterine polyps might be confirmed by an endometrial. In the proliferative phase, the hormone. Pelvic pain and cramping may start before a menstrual period and last for days into it. The end of your follicular phase is a particularly fertile period, when your odds of getting pregnant increase if you have sex. Unlike endometrial polyp, fragments of anovulatory endometrium feature uniform and densely cellular stroma without fibrosis and lack thick-walled vessels. Moreover, thickened endometrium. corpus luteum, is the primary endogenous progestational substance. Only in postmenopaus: The endometrium is the lining of the uterus, and it 'proliferates' during the 1st 1/2 of the menstrual cycle under the influence of the estrogen that. Symptoms of both include pelvic pain and heavy. Overview What is endometrial hyperplasia? Endometrial hyperplasia is when the lining of your uterus (endometrium) becomes too thick. uterus was 57. These tumors occur more frequently in postmenopausal or perimenopausal women than in premenopausal women, and >40% of these patients have a history of exogenous hormonal therapy []. The postmenopausal endometrial thickness is typically less than 5 mm in a postmenopausal woman, but different thickness cut-offs for further evaluation have been suggested. This tissue consists of: 1. 20, 21 The accuracy of. Most studies have found that the increased relative risk of developing endometrial cancer for women taking tamoxifen is two to three times higher than that of an age-matched population 1 2 3. The histologic features of what constitutes “normal” endometrium change with a woman’s age, through the premenarchal, reproductive, perimenopausal, and postmenopausal years [1,2,3]. In women with a uterus, estrogen-only HRT (unopposed estrogen) is contraindicated due to the risk of endometrial proliferative lesions, including hyperplasia and endometrioid. They should be advised to report any abnormal gynecological symptoms (vaginal bleeding or discharge) immediately, to allow for a prompt. The following can all be signs of endometrial hyperplasia: Your periods are getting longer and heavier than usual. Painful intercourse (dyspareunia) Your uterus might get bigger. An occasional mildly dilated gland is a normal feature and of no significance. This is considered a. Endometrial cancer is the fourth most common cancer in women, accounting for approximately 6,000 deaths per year in the United States. Abnormal (dysfunctional) uterine bleeding. In fact, Hysteroscopic diagnosis of endometrial hyperplasia was. INTRODUCTION. AUB is a debilitating symptom that affects up to one third of reproductive-aged women; comprehensive knowledge of menstrual cycle. Atrophy of uterus, acquired. Secretory Endometrium, SYMPTOMS -Menorrhagia, Metrorhagia (Epimenorrhea), Dysmenorrhea and more. Proliferative phase. There is a list of common symptoms of blocked fallopian tubes: abnormal vaginal discharge; painful menstruation; pain in the pelvis; abdominal pain; problems with getting pregnant;(2) Atrophic/weakly proliferative endometria were defined by the following criteria: (a) a shallow endometrium 2. Obstetrics and Gynecology 42 years experience. 1%) had a thickness greater than 20 mm. Pelvic pain. While risk factors vary, some conditions that cause too much of the hormone estrogen can lead to endometrial. The term “proliferative” means that cells are multiplying and spreading. 0001). in their study found that Positive predictive value of HYS in the diagnosis of endometrial hyperplasia accounted for 63%. The histologic types of glandular cells are columnar or cuboid. Definition. Stroma (endometrial stroma) The structure and activity of a functional endometrium reflect the pattern of ovarian hormone secretion. Dr. Decidualization is a progesterone-dependent process that ensures the endometrium adapts from a proliferative phenotype to one that will nurture and support a pregnancy. Endometrial stromal sarcoma, specifically, develops in the supporting connective tissue (stroma) of the uterus. Although endometrial polyps are relatively common and may be accompanied by abnormally heavy bleeding at menstruation. Endometrial polyps. Absolutely not: Disordered proliferative endometrium solely describes endometrium that is in different phases of development of secretory glands at the same time. Some women are badly affected, while others might not have any noticeable symptoms. Created for people with ongoing healthcare needs but benefits everyone. EMCs. However, certain conditions can develop if the cell growth is disordered. When this tissue is analyzed under a microscope, a provider may see abnormal cells and cells that could be cancerous. 2% vs 0. Noteworthy is the fact that in most reports on PMB, malignancy of the uterus is not a common finding, incidence reported ranged from 3% to 14. They can affect the function of the uterus and the surrounding organs, depending on where they grow and put pressure. 00 became effective on October 1, 2023. Endometrial ablation is a medical procedure that may relieve menorrhagia, or heavy menstrual bleeding. It's normal and usually means you can avoid major surgery if you have bleeding. Symptoms of cutaneous endometriosis often correspond with the menstrual cycle. Endometrial biopsy is a safe, efficient, and cost-effective method for evaluating the endometrium. 0; range, 1. Patient may also complain of hypomenorrhoea, secondary amenorrhoea, and infertility. , proliferative endometrium. If endometrial cancer is found early, surgically removing the uterus often cures it. The epithelial surface lining usually resembles proliferative endometrium but, in polyps originating in the lower uterine segment, it is occasionally composed of columnar cells, resembling normal endocervical lining. A proliferative endometrium is a normal part of healthy uterine function when it occurs during the first half of the menstrual cycle. Proliferative activity is relatively common in postmenopausal women ~25% and probably associated with a small increased risk of malignancy. Lifestyle factors such as inactivity, overexercise, starvation, smoking, etc. Screening for endocervical or endometrial cancer. The tissue thickens, sheds. Secretory endometrium, seen in 71 cases (32. Endometriosis. Some women are badly affected, while others might not have any noticeable symptoms. The selection criteria for admission into the study were: (1) cessation of menstruation for at least five years; (2) absence of hormonal treatment or irradiation during the menopause;. surgery, where the endometrial-like tissue is removed. Immune cells in normal cycling endometrium. 0 cm with a large single feeding artery. Obstetrics and Gynecology 20 years experience. 02), and nonatypical endometrial hyperplasia (2. Discussion 3. An endometrial polyp is an overgrowth of the endometrial lining on the inside of the uterine cavity, most often found in women between 20 and 40 years of age. Endometrium: Weakly proliferative endometrium Normal proliferative endometrium Disordered proliferativeDisordered proliferative Endometrial hyperplasia Asynchronously developed endometrium Persistent Proliferative Dilated proliferativeDilated proliferative type glands, with pseudostratification Focal breakdown common Due to unopposed. It can get worse before and during your period. Most cases of endometrial hyperplasia result from high levels of estrogens, combined with insufficient levels of the progesterone-like hormones which ordinarily counteract estrogen's proliferative effects on this tissue. Should be easily regulated with. This type of endomet. The endometrium becomes thicker leading up to ovulation to provide a suitable environment for a fertilized egg to grow inside the uterus. It is a normal finding in women of reproductive age. Your endometrial tissue will begin to thicken later in your cycle. Any form of hyperplastic endometrial pathology in menopause requires close attention, since each of the described proliferative conditions of the endometrium can. Endometrial polyps refer to overgrowths of endometrial glands and stroma within the uterine cavity. Ed Friedlander and 4 doctors agree. Comprehensive understanding of. In some cases, postmenopausal endometriosis may appear as menopausal symptoms, such as. However, there is considerable debate about whether and at which. the proliferative phase, with glandular epithelium exhibiting the strongest expression. During the menstrual cycle, the endometrium grows under the influence of two major hormones – estrogen and progesterone. The Proliferative Phase. 5 years; P<. A system of nomenclature for the description of normal uterine bleeding and the various symptoms that comprise abnormal bleeding has also been included. The definition of abnormal uterine bleeding is inconsistent with any of the four items of normal menstrual frequency, regularity, menstrual duration, and menstrual. Decidualization is a progesterone-dependent process that ensures the endometrium adapts from a proliferative phenotype to one that will nurture and support a pregnancy. Even in a worst-case scenario, the prognosis of endometrial cancer is relatively good compared to other gynecologic. 1. Topical progesterone is used to manage menopause-related symptoms, such as hot flashes, low libido, and mood swings. Doctoral Degree. 8% vs 1. There are various synthetic preparations of estrogens that are largely given to perimenopausal or postmenopausal women to treat menopausal symptoms. During the follicular phase, your ovaries house a developing egg they will later release during ovulation. Adenomyosis: symptoms, histology, and pregnancy terminations. It is also seen in exogenous estrogen therapy and is a result of dys-synchronous growth of the. Methods. 1. Endometrium contains both oestrogen and progesterone receptors,. This knowledge is important as timely surgical removal of tumour would result in remission of symptoms of irregular vaginal bleeding as well as would prevent adverse effects of prolonged. The aim of this review is to update current issues and provide a classification with a practical clinicopathological approach. One in three patients with adenomyosis is asymptomatic, but the rest may present with heavy. Lesions appear at multiple locations, present with variation in appearance, size and depth of invasion. This. They are believed to be related to oestrogen stimulation, this may be as a result of an increased. Endometritis is inflammation of the endometrium (the inner lining of your uterus) due to infection. Endometrial hyperplasia is an increased growth of the endometrium. Hereditary cancer syndromes: We don’t normally screen for endometrial cancer in. There is the absence of significant cytological atypia (Kurman et al. A hysterectomy makes it impossible for you to become pregnant in the future. dometrium is the mucous membrane that is found lining the inside of erus, and the term ‘Disordered Proliferative Endometrium’ is used to be a hyperplastic appearance of the endometrium without an increase in dometrial volume. Secretory endometrium stage. The significance of the findings is that the metaplasia may present. Commonly cited causes include transvaginal infection, intrauterine devices (IUDs), submucosal leiomyoma, and endometrial polyp; in other words, almost any cause of chronic irritation to the endometrium may result in a chronic inflammatory reaction. Irregular proliferative or luteal phase endometrium may have irregular topography and can be falsely interpreted as endometrial polyps. When the endometrium was examined, different histopathological patterns were found; the majority of the diagnoses were explained by functional causes. Very heavy periods. 1, 2 This office procedure is commonly performed for evaluation of abnormal uterine bleeding and. In pre-menopausal women, this. During this phase, your estrogen levels rise. Proliferative endometrium, showing extensive “telescoping” artifact, producing numerous double-barreled lumina, simulating complex hyperplasia. Endometrial hyperplasia is a condition of excessive proliferation of the cells of the endometrium, or inner lining of the uterus. Endometrial polyps are overgrowths of endometrial glands that typically protrude into the uterine cavity. There were some proliferative endometria with cystically dilated glands that were indistinguishable from a disordered proliferative, or anovulatory, endometrium. Go to: Etiology Abnormal genital bleeding is often attributed to the uterus, with postmenopausal women describing bleeding as “having a period” again despite not having had menses for quite some time. Menopausal symptoms are another frequent clinical presentation. As PMB is the cardinal sign of endometrial carcinoma, all postmenopausal patients with unanticipated PMB should be evaluated for endometrial. The steroid hormone progesterone plays a key role in female reproduction Citation 1. When we encounter symptoms such as abnormal uterine bleeding, it can be any of these alterations: myomas, endometrial polyps, adenomyosis, endometrial hyperplasia, or. During menses, the endometrium is shed and estrogen levels rise. You just need something to help regulate cycles. 2014b). Symptoms. Hormone Therapy: Treatment in which estrogen and often progestin are taken to help relieve symptoms that may happen around the time of menopause. The other main leukocytes of normal endometrium are CD56 + uterine natural killer (uNK) cells which account for 2% of stromal cells in proliferative endometrium, 17% during late secretory phase and more than 70% of endometrial leukocytes at the end of the first trimester of pregnancy where they play a role in. Tucker A. Follow-up of. 9 (53–89). An excessively proliferative endometrium can lead to endometrial hyperplasia, which has the potential of progression to, or can occur. Stimulates rapid endometrial growth and regeneration of glandular stumps B. Disordered proliferative endometrium is common in the perimenopausal years because of anovulatory cycles [5,6]. Read More. When: From the end of the period until ovulation. Intramural fibroids can cause symptoms that mimic those of subserosal or submucosal fibroids. 3% of the asymptomatic. The differ in that the former involves tissue growth into the muscular wall of the uterus, while the latter involves tissue growth outside of the uterus into surrounding organs. 3 years whereas mean age of serous papillary carcinoma of uterus was 62 yrs. Affected women may experience episodes of bleeding between their periods. Most endometrial biopsies from women on sequential HRT show weak secretory features. If there. In about a quarter of cases, ectopic epithelium is functional and may show signs of atrophy, metaplasia or decidual change. It is an inflammatory, estrogen-dependent condition associated with pelvic pain and infertility. A note from Cleveland Clinic. DDx. 62% of our cases with the highest incidence in 40-49 years age group. 9%; P<. It is a chronic, inflammatory, gynecologic disease marked by the presence of endometrial-like tissue outside the uterus, which in many patients is associated with debilitating painful symptoms. A subgroup of proliferative uterine adenomyosis shows proliferation of adenomyotic glandular tissue and proliferative endometrial polyp. Hemosiderin is generally absent, and glands are normally multiple and sometimes irregularly shaped. The term proliferative endometrium refers to the state of… Common Symptoms. 4%), was the most common. That will create order in your disordered endometrial lining. The follicular phase of the female menstrual cycle includes the maturation of ovarian follicles to prepare one of them for release during ovulation. 18 Although the prevalence of endometrial cancer increases with age, close to one-fourth of new diagnoses occur in. just reading about or looking for understanding of "weakly prolif endometrium" was part of my biopsy results. Introduction. 0001). The percentage of women with proliferative endometrium at month 12 ranged from 0. (48. Benign Endometrial Hyperplasia can lead to signs and symptoms, such as abnormal vaginal bleeding/discharge, and the presence of a polypoid mass in the endometrium; The most important and significant complication of Benign Endometrial Hyperplasia is that it portends a high risk for endometrial carcinoma (sometimes, as. 62 CI 0. In addition, when these women withdrew soy from the diet, their endometrial symptoms were alleviated.